General Information

  • ID:  hor005300
  • Uniprot ID:  P69096
  • Protein name:  Peptide YY-like
  • Gene name:  NA
  • Organism:  Squalus acanthias (Spiny dogfish)
  • Family:  NPY family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Squalus (genus), Squalidae (family), Squaliformes (order), Squalomorphii, Selachii (infraclass), Elasmobranchii (subclass), Chondrichthyes (class), Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007165 signal transduction
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  YPPKPENPGEDAPPEELAKYYSALRHYINLITRQRY
  • Length:  36
  • Propeptide:  YPPKPENPGEDAPPEELAKYYSALRHYINLITRQRY
  • Signal peptide:  NA
  • Modification:  T36 Tyrosine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Elicits an increase in arterial blood pressure.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-P69096-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    AF-P69096-F1.pdbhor005300_AF2.pdbhor005300_ESM.pdb

Physical Information

Mass: 491525 Formula: C196H294N52O57
Absent amino acids: CFMVW Common amino acids: P
pI: 7.52 Basic residues: 6
Polar residues: 10 Hydrophobic residues: 8
Hydrophobicity: -124.17 Boman Index: -9100
Half-Life: 2.8 hour Half-Life Yeast: 10 min
Half-Life E.Coli: 2 min Aliphatic Index 62.5
Instability Index: 7786.11 Extinction Coefficient cystines: 7450
Absorbance 280nm: 212.86

Literature

  • PubMed ID:  NA
  • Title:  Isolation and primary structure of the peptide Y from the pancreas of the spiny dogfish, Squalus acanthias.